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ACUTE DISSEMINATED ENCEPHALOMYELITIS IN CHILDREN: FOCUS ON RELAPSING PATIENTS AND PROGNOSTIC FACTORS FOR RELAPSE
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Abstract
We studied on 72 children presented with acute disseminated encephalomyelitis in Vietnam National Children’s Hospital from February 2018 to January 2023 to evaluate prognostic factors for relapse after ADEM in children. Results: during the follow-up period of 26.9 ± 17.4 months (min: 6 months, max: is 63 months), twenty (27,8%) of included patients had relapsed attacks with the following phenotypes: multiple disseminated encephalomyelitis and acute disseminated encephalomyelitis - optic neuritis. There were no statistically significant differences in clinical characteristics and MRI lesions between relapsing group and monophasic group. A positive MOG –IgG in serum increases the risk of relapse by 4.33 times (p < 0.05).
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Keywords
acute disseminated encephalomyelitis, relapse, MOG- IgG
References
2. Suppiej A, Vittorini R, Fontanin M, et al. Acute disseminated encephalomyelitis in children: focus on relapsing patients. Pediatr Neurol. 2008; 39(1): 12-17. doi:10.1016/ j.pediatrneurol.2008. 03.009
3. Mikaeloff Y, Caridade G, Husson B, Suissa S, Tardieu M, Neuropediatric KIDSEP Study Group of the French Neuropediatric Society. Acute disseminated encephalomyelitis cohort study: prognostic factors for relapse. Eur J Paediatr Neurol EJPN Off J Eur Paediatr Neurol Soc. 2007; 11(2): 90-95. doi: 10.1016/j.ejpn.2006. 11.007
4. López-Chiriboga AS, Majed M, Fryer J, et al. Association of MOG-IgG Serostatus With Relapse After Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG-Associated Disorders. JAMA Neurol. 2018;75(11): 1355-1363. doi:10.1001/jamaneurol.2018.1814
5. Yamaguchi Y, Torisu H, Kira R, et al. A nationwide survey of pediatric acquired demyelinating syndromes in Japan. Neurology. 2016;87(19): 2006-2015. doi:10.1212/WNL. 0000000000003318
6. Tenembaum S, Chamoles N, Fejerman N. Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients. Neurology. 2002;59(8):1224-1231. doi:10.1212/ wnl.59.8.1224
7. Taghdiri MM, Amouzadeh MH, Esmail Nejad SS, Abasi E, Alipour A, Akhavan M. Epidemiological, Clinical, and Laboratory Characteristics of Acute Disseminated Encephalomyelitis in Children: A Retrospective Study. Iran J Child Neurol. 2019;13(4):65-73.
8. Kariyawasam S, Singh RR, Gadian J, et al. Clinical and radiological features of recurrent demyelination following acute disseminated encephalomyelitis (ADEM). Mult Scler Relat Disord. 2015;4(5):451-456. doi:10.1016/ j.msard.2015.06.013
9. Santoro JD, Chitnis T. Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface with MOG Antibody. Neuropediatrics. 2019;50(5):273-279. doi:10.1055/s-0039-1693152