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Date Published: 13/11/2022
Abstract Views: 248
Views PDF: 157
DOI: https://doi.org/10.51298/vmj.v519i2.3612
Issue
Vol. 519 No. 2 (2022)
Section
Các bài báo
How to Cite
Thị Lan Chi, N. ., Trần Hưng, H. ., & Quang Thuận, L. . (2022). RESULTS OF 1,5-VOLUME PLASMA EXCHANGE THERAPY IN ACUTE LIVER FAILURE DUE TO ACUTE POISONING. Vietnam Medical Journal, 519(2). https://doi.org/10.51298/vmj.v519i2.3612

RESULTS OF 1,5-VOLUME PLASMA EXCHANGE THERAPY IN ACUTE LIVER FAILURE DUE TO ACUTE POISONING

Nguyễn Thị Lan Chi1,2,, Hà Trần Hưng1,3, Lê Quang Thuận1,3
1 Hanoi Medical University
2 Hung Vuong General Hospital, Phu Tho Province
3 Poison Control Center, Bach Mai Hospital

Main Article Content

Abstract

Objectives: to assesss the results of 1,5-volume plasma exchange therapy in the patients with acute liver failure due to acute poisoning. Methodology: This combined retrospective and prospective observational study was conducted in 68 patients with acute liver failure due to poisoning received 1,5-volume plasma exchange therapy at the Poison Control Center of Bach Mai Hospital. Results: Among 68 studied patients, the average age was 48,9 ± 17,24 years old. 52% were male and 48% were female. The total 186 of 1,5 volume plasma exchange sessions was performed. 1,5-volume plasma exchange therapy had improved coagulation functions with the percentage of PT% increased from 36,0 ± 22,72 to 69,4 ± 13,53, the INR ratio was improved (from 3,1 ± 2,33 to 1,2 ± 0,15), total bilirubin decreased from 290,5 ± 273,8 to 134,5 ± 142 µmol/L. The serum NH3 levels decreased from 104,9 ± 101,0 to 61,0 ± 56,6. The fatality was relatively low (27,95%). Conclusion: 1,5-volume plasma exchange therapy revealed good results, that improved blood coagulation functions, reduced bilirubin, NH3 levels and reduced mortality rate.

Article Details

Keywords

1,5 volume plasma exchange, liver failure, acute poisoning

References

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