ĐẶC ĐIỂM CỦA BỆNH NHÂN ĐA U TỦY CÓ KHUẾCH ĐẠI 1q21 TẠI BỆNH VIỆN TRUYỀN MÁU HUYẾT HỌC

Abstract

Objectives: describe characteristics of clinical symptoms, laboratory values at diagnosis and genetic features in multiple myeloma patients with amplification of chromosome 1q. Methods: cross-sectional descriptive studies are retrospective. Subjects: 95 patients newly diagnosed with multiple myeloma were included in this study at Blood transfusion hematology hospital from January 2017 to December 2020. Results: the frequency of patients with chromosome 1q amplification was 29,5% (n = 28). Among the clinical abnormalities, anemia and bone pain were the most common (>70%). There were no difference between patients with and without 1q amplification in plasmacytoma, weight loss, fever and hemorrhage. However, hypercalcaemia, Beta-2-microglobulin level, late stage of disease, multiple chromosomal abnormalities and high-risk genetic abnormalities were significant difference between 2 groups (p < 0.05). Conclusion: There are differences in the biological characteristics of the patients with chromosome 1q amplification, indicating that this group of patients belongs to the high-risk group.